Catalog: YT5035
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
Main Information
Target
Glutamine synthetase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
42kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Gl Syn Polyclonal Antibody detects endogenous levels of Gl Syn protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
42kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
More→
Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Gl Syn. AA range:295-344
show all
Specificity:
Gl Syn Polyclonal Antibody detects endogenous levels of Gl Syn protein.
show all
Gene Name:
GLUL
show all
Protein Name:
Glutamine synthetase
show all
Other Name:
GLUL ;
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
GLNS ;
Glutamine synthetase ;
GS ;
Glutamate decarboxylase ;
Glutamate--ammonia ligase
show all
Database Link:
Background:
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification , acid-base homeostasis , cell signaling , and cell proliferation. Glutamine is an abundant amino acid , and is important to the biosynthesis of several amino acids , pyrimidines , and purines. Mutations in this gene are associated with congenital glutamine deficiency , and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2 , 5 , 9 , 11 , and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq , Dec 2014] ,
show all
Function:
Catalytic activity:ATP + L-glutamate + NH (3) = ADP + phosphate + L-glutamine. ,Disease:Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum , urine and cerebrospinal fluid. ,online information:Glutamine synthetase entry ,similarity:Belongs to the glutamine synthetase family. ,subunit:Homooctamer. ,
show all
Cellular Localization:
Cytoplasm , cytosol . Microsome . Mitochondrion . Cell membrane ; Lipid-anchor . Mainly localizes in the cytosol , with a fraction associated with the cell membrane. .
show all
Tissue Expression:
show all
Research Areas:
>>Arginine biosynthesis ;
>>Alanine , aspartate and glutamate metabolism ;
>>Glyoxylate and dicarboxylate metabolism ;
>>Nitrogen metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Necroptosis ;
>>Glutamatergic synapse ;
>>GABAergic synapse
>>Alanine , aspartate and glutamate metabolism ;
>>Glyoxylate and dicarboxylate metabolism ;
>>Nitrogen metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of amino acids ;
>>Necroptosis ;
>>Glutamatergic synapse ;
>>GABAergic synapse
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT5035
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}