Recombinant Protein derived from human PGP9.5. AA range:120-170

This antibody detects endogenous levels of human PGP9.5

UCHL1

PGP9.5

Ubiquitin carboxyl-terminal hydrolase isozyme L1 ;
UCH-L1 ;
EC 6.-.-.- ;
Neuron cytoplasmic protein 9.5 ;
PGP 9.5 ;
PGP9.5 ;
Ubiquitin thioesterase L1 ;

The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq , Sep 2009] ,

Catalytic activity:Thiol-dependent hydrolysis of ester , thioester , amide , peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) . ,Disease:Oxidation of Met-1 , Met-6 , Met-12 , Met-124 and Met-179 to methionine sulfoxide , and oxidation of Cys-220 to cysteine sulfonic acid have been observed in brains from Alzheimer disease (AD) and Parkinson disease (PD) patients. In AD , UCHL1 was found to be associated with neurofibrillary tangles. ,Function:Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. ,miscellaneous:In contrast to UCHL3 , does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8. ,online information:Ubiquitin carboxy-terminal hydrolase L1 entry ,PTM:O-glycosylated. ,similarity:Belongs to the peptidase C12 family. ,subunit:Homodimer. Interacts with SNCA (By similarity) . Interacts with COPS5. ,tissue specificity:Found in neuronal cell bodies and processes throughout the neocortex (at protein level) . Expressed in neurons and cells of the diffuse neuroendocrine system and their tumors. Weakly expressed in ovary. ,

Cytoplasm . Endoplasmic reticulum membrane ; Lipid-anchor . About 30% of total UCHL1 is associated with membranes in brain.

>>Parkinson disease ;
>>Pathways of neurodegeneration - multiple diseases