Ezrin/Radixin/Moesin (Phospho Thr567/Thr564/Thr558) (PT0916R) PT™ Rabbit mAb
-YM8685
Catalog: YM8685
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Moesin/Ezrin/Radixin Phospho Thr567/Thr564/Thr558
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
69kD (Calculated)
75kD (Moesin), 80kD (Ezrin and Radixin) (Observed)
Conjugate/Modification
phosphate
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Ezrin/Radixin/Moesin (Phospho Thr567/Thr564/Thr558) Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein only when phosphorylated at Thr567/Thr564/Thr558.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YKtLR
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
69kD
MW(Observed)
75kD (Moesin), 80kD (Ezrin and Radixin)
Modification
phosphate
Clonality
Monoclonal
Clone Number
PT0916R
Isotype
IgG,Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Ezrin/Radixin/Moesin (Phospho Thr567/Thr564/Thr558) Antibody detects endogenous levels of Moesin/Ezrin/Radixin protein only when phosphorylated at Thr567/Thr564/Thr558.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):YKtLR
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Gene Name:
MSN
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Protein Name:
Moesin
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Other Name:
MSN ;
Moesin ;
Membrane-organizing extension spike protein ;
RDX ;
Radixin ;
EZR ;
VIL2 ;
Ezrin ;
Cytovillin ;
Villin-2 ;
p81
Moesin ;
Membrane-organizing extension spike protein ;
RDX ;
Radixin ;
EZR ;
VIL2 ;
Ezrin ;
Cytovillin ;
Villin-2 ;
p81
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Database Link:
Background:
Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008],
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Function:
Function:Probably involved in connections of major cytoskeletal structures to the plasma membrane.,PTM:Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.,similarity:Contains 1 FERM domain.,subcellular location:Phosphorylated form is enriched in microvilli-like structures at apical membrane.,subunit:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1.,tissue specificity:In all tissues and cultured cells studied.,
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Cellular Localization:
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, microvillus . Phosphorylated form is enriched in microvilli-like structures at apical membrane. Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment (By similarity). Localizes at the uropods of T lymphoblasts. .
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Tissue Expression:
Research Areas:
>>Tight junction ;
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Measles ;
>>Proteoglycans in cancer
>>Leukocyte transendothelial migration ;
>>Regulation of actin cytoskeleton ;
>>Measles ;
>>Proteoglycans in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8685
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$340.00
3 weeks
0
40μL
$190.00
3 weeks
0
Add to cart
Collected
Collect
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