Tropomyosin α Polyclonal Antibody

    • Catalog No.:YT4746
    • Applications:WB,ELISA
    • Reactivity:Human,Mouse,Rat
    • Description
    • Gene Name:
    • TPM1
    • Protein Name:
    • Tropomyosin alpha-1 chain
    • Human Gene Id:
    • 7168
    • Human Swiss Prot No:
    • P09493
    • Mouse Swiss Prot No:
    • P58771
    • Immunogen:
    • The antiserum was produced against synthesized peptide derived from human Tropomyosin alpha. AA range:40-89
    • Specificity:
    • Tropomyosin α Polyclonal Antibody detects endogenous levels of Tropomyosin α protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Rabbit
    • Dilution:
    • Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • TPM1; C15orf13; TMSA; Tropomyosin alpha-1 chain; Alpha-tropomyosin; Tropomyosin-1
    • MolecularWeight(Da):
    • 32709
    • Observed Band(KD):
    • 35
    • Background:
    • TPM1 is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The tropomyosin alpha-1 chain is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy.
    • Function:
    • response to reactive oxygen species, in utero embryonic development, regulation of systemic arterial blood pressure by norepinephrine-epinephrine, positive regulation of heart rate by epinephrine-norepinephrine, regulation of heart rate, heart morphogenesis, muscle system process, circulatory system process, heart process, regulation of systemic arterial blood pressure mediated by a chemical signal, regulation of heart rate by chemical signal, positive regulation of heart rate by epinephrine, regulation of systemic arterial blood pressure, cell motion, muscle contraction, regulation of muscle contraction, striated muscle contraction, response to oxidative stress, cytoskeleton organization, heart development, muscle organ development, blood circulation, regulation of heart contraction, regulation of blood pressure, response to wounding, embryonic development ending in birth or egg hatchin
    • Products Images
    • Western Blot analysis of various cells using Tropomyosin α Polyclonal Antibody. Secondary antibody(catalog#:RS0002) was diluted at 1:20000
    • Western blot analysis of lysate from HeLa cells, using Tropomyosin α antibody.