β-actin (PTR2364) mouse mAb

    • Catalog No.:YM3028
    • Applications:IF;WB;ELISA
    • Reactivity:Human;Rat;Mouse;Mk;Dg;Ch;Hamster;Rabbit;Insect;Pig;Lenok
      • Target:
      • Actin β
      • Fields:
      • >>Rap1 signaling pathway;>>Phagosome;>>Apoptosis;>>Hippo signaling pathway;>>Focal adhesion;>>Adherens junction;>>Tight junction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Leukocyte transendothelial migration;>>Thermogenesis;>>Regulation of actin cytoskeleton;>>Thyroid hormone signaling pathway;>>Oxytocin signaling pathway;>>Gastric acid secretion;>>Amyotrophic lateral sclerosis;>>Bacterial invasion of epithelial cells;>>Vibrio cholerae infection;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Yersinia infection;>>Influenza A;>>Proteoglycans in cancer;>>Hepatocellular carcinoma;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Viral myocarditis;>>Fluid shear stress and atherosclerosis
      • Gene Name:
      • ACTB
      • Protein Name:
      • Actin cytoplasmic 1
      • Human Gene Id:
      • 60
      • Human Swiss Prot No:
      • P60709
      • Mouse Swiss Prot No:
      • P60710
      • Immunogen:
      • Synthetic Peptide of β-actin
      • Specificity:
      • The antibody detects endogenous β-actin protein.
      • Formulation:
      • PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
      • Source:
      • Monoclonal, Mouse
      • Dilution:
      • IF 1:50-200 WB 1:5000-20000
      • Purification:
      • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • ACTB;Actin; cytoplasmic 1;Beta-actin;Actin β;β-Actin;Beta actin
      • Observed Band(KD):
      • 43kD
      • Background:
      • This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008],
      • Function:
      • disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the
      • Subcellular Location:
      • Cytoplasm, cytoskeleton . Nucleus . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .
      • Expression:
      • B-cell lymphoma,Brain,Cajal-Retzius cell,Eye,Fetal brain cortex,Foreskin,Hepatocellular car

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      • Postsurgical wound management and prevention of triple-negative breast cancer recurrence with a pryoptosis-inducing, photopolymerizable hydrogel JOURNAL OF CONTROLLED RELEASE Sanjun Shi WB Mouse 4 T1 cell
      • Wang, Yue, et al. "Fetal exposure to dichloroacetic acid and impaired cognitive function in the adulthood." Brain and Behavior 10.10 (2020): e01801.
      • Kang, Tze Zhen Evangeline, et al. "The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer." Journal of Biological Chemistry 296 (2021).
      • Zhuang, Hao, et al. "Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma." Cell death & disease 10.3 (2019).
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      • Tang, Qiusha, et al. "Combination of PEI-Mn0. 5Zn0. 5Fe2O4 nanoparticles and pHsp 70-HSV-TK/GCV with magnet-induced heating for treatment of hepatoma." International journal of nanomedicine 10 (2015): 7129.
      • Wang, Wu M., et al. "MicroRNA-182 regulates neurite outgrowth involving the PTEN/AKT pathway." Frontiers in cellular neuroscience 11 (2017): 96.
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      • Xu, Yingming, et al. "The spinal NR2BR/ERK2 pathway as a target for the central sensitization of collagen-induced arthritis pain." PloS one 13.7 (2018): e0201021.
      • Wang, Jun-Jie, et al. "Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3 hours before model establishment." Neural regeneration research 14.3 (2019): 452.
      • Wen, Jiexia, et al. "Essential role of Na+/Ca2+ exchanger 1 in smoking-induced growth and migration of esophageal squamous cell carcinoma." Oncotarget 7.39 (2016): 63816.
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      • Western blot analysis of Hela (1) Rat brain (2) Mouse brain (3) Chicken lung (4) and Rabbit testis (5), diluted at 1:10000.
      • Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-β-actin (PTR2364) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: AGS Lane 2: A375 Lane 3: A431 Lane 4: A549 Lane 5: ACHN Lane 6: Daudi Lane 7: Du145 Lane 8: H69AR Lane 9: HACAT Lane 10: HepG2 Predicted band size: 42kDa Observed band size: 42kDa
      • Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-β-actin (PTR2364) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: HUVEC Lane 2:JAR Lane 3:Jurkat Lane 4:LN18 Lane 5:MCF7 Lane 6:MES-SA Lane 7:MG-63 Lane 8:MRC-5 Lane 9:NIH-3T3 Lane 10:OVCAR-3 Predicted band size: 42kDa Observed band size: 42kDa
      • Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-β-actin (PTR2364) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: PC-3 Lane 2: PC-12 Lane 3: Raji Lane 4: Ramos Lane 5: Saos-2 Lane 6: RAW264.7 Lane 7: SH-SY5Y Lane 8: SW480 Lane 9: T47D Lane 10: U2OS Predicted band size: 42kDa Observed band size: 42kDa
      • Various whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-β-actin (PTR2364) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody. Lane 1: U-87 MG Lane 2: Karpas-299 Lane 3: Hela Lane 4: HEK293 Lane 5: Mouse Lung Lane 6: mouse testis Lane 7: Rabbit brain Predicted band size: 42kDa Observed band size: 42kDa