S100A1 (PT1428) Mouse mAb
- 货号:YM4119
- 应用:IHC;ELISA
- 种属:Human; Mouse (predicted: Rat)
- 免疫原:
- Synthesized peptide derived from human S100A1 AA range: 1-50
- 特异性:
- This antibody detects endogenous levels of S100A1 at Human
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源:
- Mouse, Monoclonal/IgG1, Kappa
- 稀释:
- IHC 1:200-400,ELISA 1:5000-20000
- 纯化工艺:
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- Protein S100-A1 (S-100 protein alpha chain;S-100 protein subunit alpha;S100 calcium-binding protein A1)
- 背景:
- S100 calcium binding protein A1(S100A1) Homo sapiens The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008],
- 功能:
- function:Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.,similarity:Belongs to the S-100 family.,similarity:Contains 2 EF-hand domains.,subunit:Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain.,tissue specificity:Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.,
- 细胞定位:
- Nuclear, Cytoplasmic
- 组织表达:
- Highly prevalent in heart (PubMed:12804600, PubMed:1384693). Also found in lesser quantities in skeletal muscle and brain (PubMed:1384693).
- Human kidney tissue was stained with Anti-S100A1 (ABT226) Antibody
- Human renal clear cell carcinoma tissue was stained with Anti-S100A1 (ABT226) Antibody
- Human tonsil tissue was stained with Anti-S100A1 (ABT226) Antibody