• 靶点：
• TBLR1

• 简介：
• >>Wnt signaling pathway

• 基因名称：
• TBL1XR1

• 蛋白名称：
• F-box-like/WD repeat-containing protein TBL1XR1

• Human Gene Id：
• 79718

• Human Swiss Prot No：
• Q9BZK7

• Mouse Gene Id：
• 81004

• Mouse Swiss Prot No：
• Q8BHJ5

• 免疫原：
• Purified recombinant human TBL1XR1 protein fragments expressed in E.coli.

• 特异性：
• TBL1XR1 Monoclonal Antibody detects endogenous levels of TBL1XR1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:1000 - 1:2000. IHC 1:500 - 1:1000. IF 1:100 - 1:500. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TBL1XR1;IRA1;TBLR1;F-box-like/WD repeat-containing protein TBL1XR1;Nuclear receptor corepressor/HDAC3 complex subunit TBLR1;TBL1-related protein 1;Transducin beta-like 1X-related protein 1

• 分子量：
• 56kD

• 背景：
• This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016],

• 功能：
• domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,simi

• 细胞定位：
• Nucleus .

• 组织表达：
• Widely expressed including the pituitary, hypothalamus, white and brown adipose tissue, muscle and liver.

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