TIGIT (PN0530) Nb-FC recombinant antibody

  • 货号:YA0645
  • 应用:ELISA
  • 种属:Human
    • 靶点:
    • TIGIT
    • 基因名称:
    • TIGIT VSIG9 VSTM3
    • 蛋白名称:
    • T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
    • Human Swiss Prot No:
    • Q495A1
    • 免疫原:
    • Purified recombinant Human TIGIT
    • 特异性:
    • This recombinant monoclonal antibody can detects endogenous levels of TIGIT protein.
    • 组成:
    • Phosphate-buffered solution
    • 来源:
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • 稀释:
    • ELISA 1:5000-100000
    • 纯化工艺:
    • Recombinant Expression and Affinity purified
    • 浓度:
    • Please check the information on the tube
    • 储存:
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • 其他名称:
    • T-cell immunoreceptor with Ig and ITIM domains;VSIG9;VSTM3;WUCAM;TIGIT nanobody;
    • 背景:
    • T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.
    • 功能:
    • Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
    • 细胞定位:
    • Cell membrane ; Single-pass type I membrane protein .
    • 组织表达:
    • Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).