• 靶点：
• CD43

• 简介：
• >>Cell adhesion molecules

• 基因名称：
• SPN CD43

• 蛋白名称：
• CD43

• Human Gene Id：
• 6693

• Human Swiss Prot No：
• P16150

• 免疫原：
• Synthesized peptide derived from human CD43 AA range: 300-400

• 特异性：
• The antibody can specifically recognize human CD43 protein.

• 来源：
• Mouse, Monoclonal/IgG2b, Kappa

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• Leukosialin (Galactoglycoprotein;GALGP;Leukocyte sialoglycoprotein;Sialophorin;CD antigen CD43)

• 背景：
• The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011],

• 功能：
• disease:CD43 expression is defective on the T-cells of males with the immunodeficiency Wiskott-Aldrich syndrome. Affected males are susceptible to opportunistic infections and do not respond to polysaccharide antigens, reflecting defects in cytotoxic and helper T-cell functions.,function:One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response.,PTM:Glycosylated; has a high c

• 细胞定位：
• Membranous

• 组织表达：
• Cell surface of thymocytes, T-lymphocytes, neutrophils, plasma cells and myelomas.

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