Catalog: YT8090
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
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Collected
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Main Information
Target
GARS
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IHC, WB
MW
81kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of SYG at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
81kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human N-ternal SYG
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Specificity:
This antibody detects endogenous levels of SYG at Human, Mouse,Rat
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Gene Name:
GARS
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Protein Name:
Glycine--tRNA ligase (Diadenosine tetraphosphate synthetase) (AP-4-A synthetase) (Glycyl-tRNA synthetase) (GlyRS)
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Other Name:
Glycine--tRNA ligase ;
Diadenosine tetraphosphate synthetase ;
AP-4-A synthetase ;
Glycyl-tRNA synthetase ;
GlyRS ;
Diadenosine tetraphosphate synthetase ;
AP-4-A synthetase ;
Glycyl-tRNA synthetase ;
GlyRS ;
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Function:
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) . Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis .
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Cellular Localization:
Cytoplasm . Cell projection, axon . Secreted . Secreted, extracellular exosome . In transfected COS7 cells, not detected in mitochondria, nor in Golgi apparatus (PubMed:17035524). Secreted by motor neuron, possibly through the exosome pathway (By similarity). .; [Isoform 1]: Mitochondrion . Cytoplasm .; [Isoform 2]: Cytoplasm . Cell projection, axon .
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Tissue Expression:
Widely expressed, including in brain and spinal cord. ; [Isoform 2]: Expressed in brain, spinal cord, muscle, heart and spleen. ; [Isoform 1]: Expressed in brain, spinal cord, muscle, heart, spleen and liver.
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Reference Citation({{totalcount}})
Catalog: YT8090
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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