Synthesized peptide derived from human OPTN

This antibody detects endogenous levels of OPTN at Human, Mouse,Rat

OPTN FIP2 GLC1E HIP7 HYPL NRP

OPTN

Optineurin ;
E3-14.7K-interacting protein ;
FIP-2 ;
Huntingtin yeast partner L ;
Huntingtin-interacting protein 7 ;
HIP-7 ;
Huntingtin-interacting protein L ;
NEMO-related protein ;
Optic neuropathy-inducing protein ;
Transcription factor IIIA-interacting protein ;
TFIIIA-IntP ;

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Cytoplasm, perinuclear region. Golgi apparatus . Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Recycling endosome. Found in the perinuclear region and associates with the Golgi apparatus (PubMed:27534431). Colocalizes with MYO6 and RAB8 at the Golgi complex and in vesicular structures close to the plasma membrane. Localizes to LC3-positive cytoplasmic vesicles upon induction of autophagy. .

Present in aqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lymphocyte, fibroblast, skeletal muscle, heart, liver, brain and placenta.

>>Mitophagy - animal ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases