Catalog: YT7964
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
EAAT2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
63kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human,Rat,Mouse EAA2
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
63kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human EAA2
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Specificity:
This antibody detects endogenous levels of Human,Rat,Mouse EAA2
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Gene Name:
SLC1A2 EAAT2 GLT1
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Protein Name:
Excitatory amino acid transporter 2
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Other Name:
Excitatory amino acid transporter 2 ;
Glutamate/aspartate transporter II ;
Sodium-dependent glutamate/aspartate transporter 2 ;
Solute carrier family 1 member 2 ;
Glutamate/aspartate transporter II ;
Sodium-dependent glutamate/aspartate transporter 2 ;
Solute carrier family 1 member 2 ;
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Database Link:
Background:
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010],
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Function:
Function:Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.,PTM:Glycosylated.,similarity:Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.,subunit:Homotrimer. Interacts with JUB.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .
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Research Areas:
>>Synaptic vesicle cycle ;
>>Glutamatergic synapse ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease
>>Glutamatergic synapse ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT7964
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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