The protein encoded by this gene acts as a homotetramer and may be involved in the conversion of S-adenosyl-L-homocysteine to L-homocysteine and adenosine. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011],
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Function:
Catalytic activity:S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.,cofactor:Binds 1 NAD per subunit.,cofactor:NAD.,pathway:Amino-acid biosynthesis; homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.,similarity:Belongs to the adenosylhomocysteinase family.,
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Cellular Localization:
Cytoplasm . Microsome . Associates with membranes when phosphorylated, probably through interaction with ITPR1. .
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Research Areas:
>>Cysteine and methionine metabolism ;
>>Metabolic pathways