Synthesized peptide derived from human DUOX1 AA range: 1398-1448

This antibody detects endogenous levels of DUOX1 at Human/Rat

DUOX1 DUOX LNOX1 THOX1

DUOX1

The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012],

Catalytic activity:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).,developmental stage:Widely expressed in fetal tissues.,enzyme regulation:The NADPH oxidase activity is calcium-dependent. Peroxidase activity is inhibited by aminobenzohydrazide.,Function:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.,induction:By forskolin (at protein level). By thyrotropin and the Th2-specific cytokines IL-4 and IL-13.,pathway:Hormone biosynthesis; thyroid hormone biosynthesis.,PTM:N-glycosylated.,sequence Caution:Translated as Arg.,similarity:Contains 1 FAD-binding FR-type domain.,similarity:Contains 1 ferric oxidoreductase domain.,similarity:Contains 3 EF-hand domains.,similarity:In the N-terminal section; belongs to the peroxidase family.,subcellular location:Localizes to the apical membrane of epithelial cells.,subunit:Interacts with TXNDC11, TPO and CYBA.,tissue specificity:Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.,

Apical cell membrane ; Multi-pass membrane protein . Localizes to the apical membrane of epithelial cells.

Expressed in thyrocytes and tracheal surface epithelial cells (at protein level). Expressed in thyroid, trachea, bronchium, and to a lower extent, in placenta, testis, prostate, pancreas and heart.

>>Thyroid hormone synthesis