Synthesized peptide derived from human DAZ4 AA range: 525-575

This antibody detects endogenous levels of DAZ4 at Human

DAZ4

DAZ4

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011],

Caution:DAZ4 is the only DAZ gene whose expression has not been clearly demonstrated. PubMed:10936047 could not exclude the possibility that the transcript they isolated derives from DAZ1.,Disease:AZFc deletions in the Yq11.23 region, including the DAZ genes, are a cause of azoospermia or oligospermia. They lead to male infertility due to impaired spermatogenesis and are found 2-10% of azoospermic or severe oligospermic males.,Disease:AZFc deletions in the Yq11.23 region, including the DAZ genes, are a cause of azoospermia or oligospermia. They lead to male infertility due to impaired spermatogenesis and are found 2-10% of azoospermic or severe oligospermic males. Some AZFc deletions remove only the DAZ and DAZ2 genes and cause severe oligozoospermia.,Domain:The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.,Function:RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.,miscellaneous:The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.,polymorphism:The number as well as the precise structure of the DAZ proteins probably differs within the population.,similarity:Belongs to the RRM DAZ family.,similarity:Contains 1 RRM (RNA recognition motif) domain.,similarity:Contains 12 DAZ-like domains.,similarity:Contains 15 DAZ-like domains.,similarity:Contains 2 RRM (RNA recognition motif) domains.,similarity:Contains 3 RRM (RNA recognition motif) domains.,similarity:Contains 9 DAZ-like domains.,subcellular location:Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.,subunit:Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.,tissue specificity:Testis specific.,

Cytoplasm . Nucleus . Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.