This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein, a component of the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA processing and may be required for cell cycle progression to S phase. Expression level and methylation status of this gene may be correlated with bone mineral density. [provided by RefSeq, Jul 2016],
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Function:
Function:Involved in histone pre-mRNA processing, most likely by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 20 C2H2-type zinc fingers.,subunit:Interacts with the SLBP/pre-mRNA complex but not with SLBP alone.,
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Cellular Localization:
Nucleus . Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.