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Catalog: YT5888
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
In stock

0

40μL
$150.00
In stock

0

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Main Information
Target

TIM-1

Host Species

Rabbit

Reactivity

Human

Applications

IHC

MW

40-50kD (Observed)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
The antibody detects endogenous TIM-1
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
40-50kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthetic peptide from human protein at AA range: 40-100
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Specificity:
The antibody detects endogenous TIM-1
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Gene Name:
HAVCR1 KIM1 TIM1 TIMD1
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Protein Name:
Hepatitis A virus cellular receptor 1 (HAVcr-1) (Kidney injury molecule 1) (KIM-1) (T-cell immunoglobulin and mucin domain-containing protein 1) (TIMD-1) (T-cell membrane protein 1) (TIM-1) (TIM)
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Other Name:
Hepatitis A virus cellular receptor 1 ;
HAVcr-1 ;
Kidney injury molecule 1 ;
KIM-1 ;
T-cell immunoglobulin and mucin domain-containing protein 1 ;
TIMD-1 ;
T-cell membrane protein 1 ;
TIM-1 ;
TIM ;
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Database Link:
Organism Gene ID SwissProt
Human 26762; Q96D42;
Mouse 171283; Q5QNS5;
Background:
The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015],
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Function:
Function:May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.,polymorphism:HHAV seropositivity protects against atopy in individuals with the variants Met-Thr-Thr-Val-Pro-157 ins and Met-Thr-Thr-Thr-Val-Pro-157 ins. Modernisation has led to a reduction in HAV seroprevalence and thus, may be, to an increase of expression of atopy, such as asthma, allergic rhinitis and atopic dermatitis. Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.,
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Cellular Localization:
Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
show all
Catalog: YT5888
Size
Price
Status
Qty.
200μL
$450.00
In stock

0

100μL
$280.00
In stock

0

40μL
$150.00
In stock

0

Add to cart

Collected

Collect

Customized Service

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