The antiserum was produced against synthesized peptide derived from the C-terminal region of human LEFTY1/LEFTY2. AA range:301-350

Lefty Polyclonal Antibody detects endogenous levels of Lefty protein.

LEFTY1/LEFTY2

Left-right determination factor 1/Left-right determination factor 2

LEFTY1 ;
LEFTB ;
LEFTYB ;
Left-right determination factor 1 ;
Left-right determination factor B ;
Protein lefty-1 ;
Protein lefty-B ;
LEFTY2 ;
EBAF ;
LEFTA ;
LEFTYA ;
TGFB4 ;
PSEC0024 ;
Left-right determination factor 2 ;
Endometrial bleeding-associated factor ;
Left-right determination factor A ;
Protein lefty-2 ;
Protein lefty-A ;
Transforming growth factor beta-4 ;
TGF-beta-4

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016],

Function:Required for left-right axis determination as a regulator of LEFTY2 and NODAL.,PTM:The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.,similarity:Belongs to the TGF-beta family.,

Secreted.

Colon,Pancreas,Spleen,Teratocarcinoma,

>>TGF-beta signaling pathway ;
>>Signaling pathways regulating pluripotency of stem cells