The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF4. AA range:31-80

Ox40L Polyclonal Antibody detects endogenous levels of Ox40L protein.

TNFSF4

Tumor necrosis factor ligand superfamily member 4

TNFSF4 ;
TXGP1 ;
Tumor necrosis factor ligand superfamily member 4 ;
Glycoprotein Gp34 ;
OX40 ligand ;
OX40L ;
TAX transcriptionally-activated glycoprotein 1 ;
CD252

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],

Disease:Genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.,Function:Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.,induction:By human T-cell leukemia virus type I transactivator P40-TAX.,similarity:Belongs to the tumor necrosis factor family.,subunit:Homotrimer.,

Membrane; Single-pass type II membrane protein.

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