Catalog: YT5544
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
Bag-3
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
80kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human BAG3. AA range:311-360
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Specificity:
Bag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
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Gene Name:
BAG3
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Protein Name:
BAG family molecular chaperone regulator 3
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Other Name:
BAG3 ;
BIS ;
BAG family molecular chaperone regulator 3 ;
BAG-3 ;
Bcl-2-associated athanogene 3 ;
Bcl-2-binding protein Bis ;
Docking protein CAIR-1
BIS ;
BAG family molecular chaperone regulator 3 ;
BAG-3 ;
Bcl-2-associated athanogene 3 ;
Bcl-2-binding protein Bis ;
Docking protein CAIR-1
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Background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
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Function:
Function:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
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Cellular Localization:
Nucleus . Cytoplasm . Colocalizes with HSF1 to the nucleus upon heat stress (PubMed:26159920). .
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Tissue Expression:
Brain,Epithelium,Liver,Lung,Placenta,T-cell,Testis,Tongue,
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Reference Citation({{totalcount}})
Catalog: YT5544
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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