Catalog: YT5351
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
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Main Information
Target
Myeloperoxidase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
85kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC: 100-300; WB 1:500-1:2000; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
MPO Polyclonal Antibody detects endogenous levels of MPO protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
85kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
RRID
AB_3675865
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the N-terminal region of human MPO. AA range:41-90
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Specificity:
MPO Polyclonal Antibody detects endogenous levels of MPO protein.
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Gene Name:
MPO
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Protein Name:
Myeloperoxidase
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Other Name:
MPO ;
Myeloperoxidase ;
MPO
Myeloperoxidase ;
MPO
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Background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor , myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq , Nov 2014] ,
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Function:
Catalytic activity:Cl (-) + H (2) O (2) = HOCl + 2 H (2) O. ,Catalytic activity:Donor + H (2) O (2) = oxidized donor + 2 H (2) O. ,cofactor:Binds 1 calcium ion per heterodimer. ,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group covalently per heterodimer. ,Disease:Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. ,Function:Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN , MPO catalyzes the production of hypohalous acids , primarily hypochlorous acid in physiologic situations , and other toxic intermediates that greatly enhance PMN microbicidal activity. ,online information:MPO mutation db ,online information:Myeloperoxidase entry ,similarity:Belongs to the peroxidase family. XPO subfamily. ,subunit:Tetramer of two light chains and two heavy chains. ,
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Cellular Localization:
Lysosome.
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Tissue Expression:
Research Areas:
>>Drug metabolism - other enzymes ;
>>Phagosome ;
>>Neutrophil extracellular trap formation ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
>>Phagosome ;
>>Neutrophil extracellular trap formation ;
>>Transcriptional misregulation in cancer ;
>>Acute myeloid leukemia
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT5351
Size
Price
Status
Qty.
200μL
$450.00
4 weeks
0
100μL
$280.00
4 weeks
0
40μL
$150.00
4 weeks
0
Add to cart
Collected
Collect
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