The antiserum was produced against synthesized peptide derived from the Internal region of human BCL6. AA range:271-320

Bcl-6 Polyclonal Antibody detects endogenous levels of Bcl-6 protein.

BCL6

B-cell lymphoma 6 protein

BCL6 ;
BCL5 ;
LAZ3 ;
ZBTB27 ;
ZNF51 ;
B-cell lymphoma 6 protein ;
BCL-6 ;
B-cell lymphoma 5 protein ;
BCL-5 ;
Protein LAZ-3 ;
Zinc finger and BTB domain-containing protein 27 ;
Zinc finger protein 51

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015],

Disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1.,Disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF.,Disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions.,Function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.,induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan.,PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 C2H2-type zinc fingers.,subunit:Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9.,tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.,

Nucleus .

Expressed in germinal center T- and B-cells and in primary immature dendritic cells.

>>FoxO signaling pathway ;
>>Transcriptional misregulation in cancer ;
>>Chemical carcinogenesis - receptor activation