Catalog: YT5234
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
LASP-1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC
MW
28kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
28kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from the Internal region of human LASP1. AA range:51-100
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Specificity:
LASP-1 Polyclonal Antibody detects endogenous levels of LASP-1 protein.
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Gene Name:
LASP1
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Protein Name:
LIM and SH3 domain protein 1
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Other Name:
LASP1 ;
MLN50 ;
LIM and SH3 domain protein 1 ;
LASP-1 ;
Metastatic lymph node gene 50 protein ;
MLN 50
MLN50 ;
LIM and SH3 domain protein 1 ;
LASP-1 ;
Metastatic lymph node gene 50 protein ;
MLN 50
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Database Link:
Background:
This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012],
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Function:
Function:Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.,PTM:Phosphorylated.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 nebulin repeats.,subcellular location:Associated with the F-actin rich cortical cytoskeleton.,subunit:Interacts with F-actin.,
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Cellular Localization:
Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Associated with the F-actin rich cortical cytoskeleton. .
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Tissue Expression:
Epithelium,Liver,Mammary carcinoma,Platelet,Skin,T-cell,
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Reference Citation({{totalcount}})
Catalog: YT5234
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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