The antiserum was produced against synthesized peptide derived from human WASF2. AA range:141-190

WAVE2 Polyclonal Antibody detects endogenous levels of WAVE2 protein.

WASF2

Wiskott-Aldrich syndrome protein family member 2

WASF2 ;
WAVE2 ;
Wiskott-Aldrich syndrome protein family member 2 ;
WASP family protein member 2 ;
Protein WAVE-2 ;
Verprolin homology domain-containing protein 2

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],

Domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,Function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subcellular location:At the interface between the lamellipodial actin meshwork and the membrane.,subunit:Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.,tissue specificity:Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.,

Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Basolateral cell membrane . At the interface between the lamellipodial actin meshwork and the membrane. .

Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

>>Adherens junction ;
>>Fc gamma R-mediated phagocytosis ;
>>Regulation of actin cytoskeleton ;
>>Bacterial invasion of epithelial cells ;
>>Pathogenic Escherichia coli infection ;
>>Shigellosis ;
>>Yersinia infection ;
>>Choline metabolism in cancer