Catalog: YT4842
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
USP45
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
90kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
USP45 Polyclonal Antibody detects endogenous levels of USP45 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
90kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human USP45. AA range:301-350
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Specificity:
USP45 Polyclonal Antibody detects endogenous levels of USP45 protein.
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Gene Name:
USP45
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Protein Name:
Ubiquitin carboxyl-terminal hydrolase 45
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Other Name:
USP45 ;
Ubiquitin carboxyl-terminal hydrolase 45 ;
Deubiquitinating enzyme 45 ;
Ubiquitin thioesterase 45 ;
Ubiquitin-specific-processing protease 45
Ubiquitin carboxyl-terminal hydrolase 45 ;
Deubiquitinating enzyme 45 ;
Ubiquitin thioesterase 45 ;
Ubiquitin-specific-processing protease 45
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Background:
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016],
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Function:
Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 UBP-type zinc finger.,tissue specificity:Broadly expressed, with highest levels in ovary, skeletal muscle and spleen.,
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Cellular Localization:
Photoreceptor inner segment . Cytoplasm . Nucleus .
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Tissue Expression:
Widely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563).
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Reference Citation({{totalcount}})
Catalog: YT4842
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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