Catalog: YT4816
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
UDP-GlcDH
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
55kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
55kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human UGDH. AA range:391-440
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Specificity:
UDP-GlcDH Polyclonal Antibody detects endogenous levels of UDP-GlcDH protein.
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Gene Name:
UGDH
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Protein Name:
UDP-glucose 6-dehydrogenase
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Other Name:
UGDH ;
UDP-glucose 6-dehydrogenase ;
UDP-Glc dehydrogenase ;
UDP-GlcDH ;
UDPGDH
UDP-glucose 6-dehydrogenase ;
UDP-Glc dehydrogenase ;
UDP-GlcDH ;
UDPGDH
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Database Link:
Background:
The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
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Function:
Catalytic activity:UDP-glucose + 2 NAD(+) + H(2)O = UDP-glucuronate + 2 NADH.,Function:Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.,pathway:Nucleotide-sugar biosynthesis; UDP-glucuronic acid biosynthesis; UDP-glucuronic acid from UDP-glucose: step 1/1.,similarity:Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.,subunit:Homohexamer.,
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Cellular Localization:
nucleus,nucleoplasm,cytosol,extracellular exosome,
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Tissue Expression:
Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970).
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Research Areas:
>>Pentose and glucuronate interconversions ;
>>Ascorbate and aldarate metabolism ;
>>Amino sugar and nucleotide sugar metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Biosynthesis of nucleotide sugars
>>Ascorbate and aldarate metabolism ;
>>Amino sugar and nucleotide sugar metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Biosynthesis of nucleotide sugars
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Reference Citation({{totalcount}})
Catalog: YT4816
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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