Catalog: YT4659
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
TIMP-2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
25kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TIMP-2 Polyclonal Antibody detects endogenous levels of TIMP-2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
25kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
TIMP-2 Rabbit pAb
YT4659
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ELISA Kits
Human TIMP-2 ELISA Kit
KE1167
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ELISA Kits
Total TIMP-2 Cell-Based Colorimetric ELISA Kit
KA3398C
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Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human TIMP2. AA range:21-70
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Specificity:
TIMP-2 Polyclonal Antibody detects endogenous levels of TIMP-2 protein.
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Gene Name:
TIMP2
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Protein Name:
Metalloproteinase inhibitor 2
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Other Name:
TIMP2 ;
Metalloproteinase inhibitor 2 ;
CSC-21K ;
Tissue inhibitor of metalloproteinases 2 ;
TIMP-2
Metalloproteinase inhibitor 2 ;
CSC-21K ;
Tissue inhibitor of metalloproteinases 2 ;
TIMP-2
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Background:
This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008],
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Function:
Function:Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.,PTM:The activity of TIMP2 is dependent on the presence of disulfide bonds.,similarity:Belongs to the protease inhibitor I35 (TIMP) family.,similarity:Contains 1 NTR domain.,
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Cellular Localization:
Secreted.
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Tissue Expression:
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Reference Citation({{totalcount}})
Catalog: YT4659
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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