Catalog: YT4210
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
SAP 14
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
14kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
SAP 14 Polyclonal Antibody detects endogenous levels of SAP 14 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
14kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human SF3B14. AA range:76-125
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Specificity:
SAP 14 Polyclonal Antibody detects endogenous levels of SAP 14 protein.
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Gene Name:
SF3B14
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Protein Name:
Pre-mRNA branch site protein p14
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Other Name:
SF3B14 ;
CGI-110 ;
HSPC175 ;
HT006 ;
Pre-mRNA branch site protein p14 ;
SF3b 14 kDa subunit
CGI-110 ;
HSPC175 ;
HT006 ;
Pre-mRNA branch site protein p14 ;
SF3b 14 kDa subunit
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Background:
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008],
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Function:
Function:Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Interacts with SF3B1/SF3b155 in the region of amino acids 255-424. Interacts to a lesser extent with SF3b130.,
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Cellular Localization:
Nucleus .
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Tissue Expression:
Hypothalamus,Testis,Umbilical cord blood,Uterus,
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Research Areas:
>>Spliceosome
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Reference Citation({{totalcount}})
Catalog: YT4210
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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