Synthesized peptide derived from RBQ-3 . at AA range: 190-270

RBQ-3 Polyclonal Antibody detects endogenous levels of RBQ-3 protein.

RBBP5

Retinoblastoma-binding protein 5

RBBP 5 ;
RBBP-5 ;
RBBP5 ;
RBBP5_HUMAN ;
RBQ-3 ;
RBQ3 ;
Retinoblastoma binding protein 5 ;
Retinoblastoma binding protein RBQ3 ;
Retinoblastoma binding protein5 ;
Retinoblastoma-binding protein 5 ;
Retinoblastoma-binding protein RBQ-3 ;
SWD1 ;
SWD1, Set1c WD40 repeat protein, homolog.

This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2010],

Function:Binds preferentially to underphosphorylated retinoblastoma protein.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 WD repeats.,subunit:Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1.,tissue specificity:Ubiquitously expressed.,

Nucleus .

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