The antiserum was produced against synthesized peptide derived from human PFKFB1. AA range:406-455

PFK-2 liv Polyclonal Antibody detects endogenous levels of PFK-2 liv protein.

PFKFB1

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

PFKFB1 ;
F6PK ;
PFRX ;
6-phosphofructo-2-kinase/fructose-2 ;
6-bisphosphatase 1 ;
6PF-2-K/Fru-2,6-P2ase 1 ;
PFK/FBPase 1 ;
6PF-2-K/Fru-2,6-P2ase liver isozyme

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012],

Catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,Catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in inhibition of the kinase activity.,Function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Liver.,

cytosol,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex,

Liver.

>>Fructose and mannose metabolism ;
>>Metabolic pathways ;
>>AMPK signaling pathway ;
>>Glucagon signaling pathway