Catalog: YT2997
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
NCoA-5
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
65kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
NCoA-5 Polyclonal Antibody detects endogenous levels of NCoA-5 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
65kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human NCOA5. AA range:345-394
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Specificity:
NCoA-5 Polyclonal Antibody detects endogenous levels of NCoA-5 protein.
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Gene Name:
NCOA5
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Protein Name:
Nuclear receptor coactivator 5
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Other Name:
NCOA5 ;
KIAA1637 ;
Nuclear receptor coactivator 5 ;
NCoA-5 ;
Coactivator independent of AF-2 ;
CIA
KIAA1637 ;
Nuclear receptor coactivator 5 ;
NCoA-5 ;
Coactivator independent of AF-2 ;
CIA
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Background:
This gene encodes a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. [provided by RefSeq, Jul 2008],
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Function:
Domain:Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.,Function:Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC/c-myc in response to 17-beta-estradiol (E2).,subunit:Binds HTATIP2/TIP30.,tissue specificity:Widely expressed.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Widely expressed.
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Reference Citation({{totalcount}})
Catalog: YT2997
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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