Catalog: YT2785
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
MLK2
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, IF, ELISA
MW
104kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
MLK2 Polyclonal Antibody detects endogenous levels of MLK2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
104kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human MAP3K10. AA range:391-440
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Specificity:
MLK2 Polyclonal Antibody detects endogenous levels of MLK2 protein.
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Gene Name:
MAP3K10
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Protein Name:
Mitogen-activated protein kinase kinase kinase 10
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Other Name:
MAP3K10 ;
MLK2 ;
MST ;
Mitogen-activated protein kinase kinase kinase 10 ;
Mixed lineage kinase 2 ;
Protein kinase MST
MLK2 ;
MST ;
Mitogen-activated protein kinase kinase kinase 10 ;
Mixed lineage kinase 2 ;
Protein kinase MST
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Background:
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.,Function:Activates the JUN N-terminal pathway.,PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH3 domain.,subunit:Homodimer.,tissue specificity:Expressed in brain and skeletal muscle.,
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Cellular Localization:
intracellular,cytoplasm,
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Tissue Expression:
Expressed in brain and skeletal muscle.
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Research Areas:
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases
>>Pathways of neurodegeneration - multiple diseases
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2785
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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