The antiserum was produced against synthesized peptide derived from human HLA-DOA. AA range:71-120

HLA-DOα Polyclonal Antibody detects endogenous levels of HLA-DOα protein.

HLA-DOA

HLA class II histocompatibility antigen DO alpha chain

HLA-DOA ;
HLA-DNA ;
HLA-DZA ;
HLA class II histocompatibility antigen ;
DO alpha chain ;
MHC DN-alpha ;
MHC DZ alpha ;
MHC class II antigen DOA

HLA-DOA belongs to the HLA class II alpha chain paralogues. HLA-DOA forms a heterodimer with HLA-DOB. The heterodimer, HLA-DO, is found in lysosomes in B cells and regulates HLA-DM-mediated peptide loading on MHC class II molecules. In comparison with classical HLA class II molecules, this gene exhibits very little sequence variation, especially at the protein level. [provided by RefSeq, Jul 2008],

Function:Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule.,polymorphism:The only allele of DOA known is DOA*0101 which is shown here.,similarity:Belongs to the MHC class II family.,similarity:Contains 1 Ig-like C1-type (immunoglobulin-like) domain.,subunit:Heterodimer of an alpha chain (DOA) and a beta chain (DOB).,

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Lymph,

>>Phagosome ;
>>Cell adhesion molecules ;
>>Antigen processing and presentation ;
>>Hematopoietic cell lineage ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>Intestinal immune network for IgA production ;
>>Type I diabetes mellitus ;
>>Leishmaniasis ;
>>Toxoplasmosis ;
>>Staphylococcus aureus infection ;
>>Tuberculosis ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Asthma ;
>>Autoimmune thyroid disease ;
>>Inflammatory bowel disease ;
>>Systemic lupus erythematosus ;
>>Rheumatoid arthritis ;
>>Allograft rejection ;
>>Graft-versus-host disease ;
>>Viral myocarditis