Catalog: YT1897
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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0
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Main Information
Target
GFRα-4
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, ELISA
MW
30kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
30kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GFRA4. AA range:141-190
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Specificity:
GFRα-4 Polyclonal Antibody detects endogenous levels of GFRα-4 protein.
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Gene Name:
GFRA4
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Protein Name:
GDNF family receptor alpha-4
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Other Name:
GFRA4 ;
GDNF family receptor alpha-4 ;
GDNF receptor alpha-4 ;
GDNFR-alpha-4 ;
GFR-alpha-4 ;
Persephin receptor
GDNF family receptor alpha-4 ;
GDNF receptor alpha-4 ;
GDNFR-alpha-4 ;
GFR-alpha-4 ;
Persephin receptor
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Background:
The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],
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Function:
Alternative products:Additional isoforms seem to exist,Function:Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.,similarity:Belongs to the GDNFR family.,tissue specificity:Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.,
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Cellular Localization:
[Isoform GFRalpha4a]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4b]: Cell membrane; Lipid-anchor, GPI-anchor.; [Isoform GFRalpha4c]: Secreted.
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Tissue Expression:
Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
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Reference Citation({{totalcount}})
Catalog: YT1897
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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