Catalog: YT1884
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
GCLM
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC, IF, ELISA
MW
31kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
GCSm-γ Polyclonal Antibody detects endogenous levels of GCSm-γ protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
31kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
More→
Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
More→
Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
More→
Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
More→
Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human GCSm-gamma. AA range:42-91
show all
Specificity:
GCSm-γ Polyclonal Antibody detects endogenous levels of GCSm-γ protein.
show all
Gene Name:
GCLM
show all
Protein Name:
Glutamate--cysteine ligase regulatory subunit
show all
Other Name:
GCLM ;
GLCLR ;
Glutamate--cysteine ligase regulatory subunit ;
GCS light chain ;
Gamma-ECS regulatory subunit ;
Gamma-glutamylcysteine synthetase regulatory subunit ;
Glutamate--cysteine ligase modifier subunit
GLCLR ;
Glutamate--cysteine ligase regulatory subunit ;
GCS light chain ;
Gamma-ECS regulatory subunit ;
Gamma-glutamylcysteine synthetase regulatory subunit ;
Glutamate--cysteine ligase modifier subunit
show all
Database Link:
Background:
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
show all
Function:
pathway:Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.,similarity:Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.,subunit:Heterodimer of a catalytic heavy chain and a regulatory light chain.,tissue specificity:In all tissues examined. Highest levels in skeletal muscle.,
show all
Cellular Localization:
cytosol,glutamate-cysteine ligase complex,
show all
Tissue Expression:
Research Areas:
>>Cysteine and methionine metabolism ;
>>Glutathione metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Ferroptosis
>>Glutathione metabolism ;
>>Metabolic pathways ;
>>Biosynthesis of cofactors ;
>>Ferroptosis
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT1884
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Recently Viewed Products
Clear allPRODUCTS
CUSTOMIZED
ABOUT US
Toggle night Mode
{{pinfoXq.title || ''}}
Catalog: {{pinfoXq.catalog || ''}}
Filter：
All
{{item.name}}
{{pinfo.title}}
-{{pinfo.catalog}}
Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Product {{index}}/{{pcount}}
Prev
Next
{{pvTitle}}
Scroll wheel zooms the picture
{{pvDescr}}