The antiserum was produced against synthesized peptide derived from human TUBGCP4. AA range:191-240

GCP4 Polyclonal Antibody detects endogenous levels of GCP4 protein.

TUBGCP4

Gamma-tubulin complex component 4

TUBGCP4 ;
76P ;
GCP4 ;
Gamma-tubulin complex component 4 ;
GCP-4 ;
hGCP4 ;
Gamma-ring complex protein 76 kDa ;
h76p ;
hGrip76

This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015],

Function:Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.,similarity:Belongs to the GCP family.,subunit:Gamma-tubulin complex is composed of gamma-tubulin, GCP2, GCP3, GCP4, GCP5 and GCP6.,tissue specificity:Ubiquitously expressed.,

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Ubiquitously expressed.