Catalog: YT1460
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
EDG-1
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
43kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
EDG-1 Polyclonal Antibody detects endogenous levels of EDG-1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
43kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human EDG1. AA range:5-54
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Specificity:
EDG-1 Polyclonal Antibody detects endogenous levels of EDG-1 protein.
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Gene Name:
S1PR1
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Protein Name:
Sphingosine 1-phosphate receptor 1
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Other Name:
S1PR1 ;
CHEDG1 ;
EDG1 ;
Sphingosine 1-phosphate receptor 1 ;
S1P receptor 1 ;
S1P1 ;
Endothelial differentiation G-protein coupled receptor 1 ;
Sphingosine 1-phosphate receptor Edg-1 ;
S1P receptor Edg-1 ;
CD antigen CD363
CHEDG1 ;
EDG1 ;
Sphingosine 1-phosphate receptor 1 ;
S1P receptor 1 ;
S1P1 ;
Endothelial differentiation G-protein coupled receptor 1 ;
Sphingosine 1-phosphate receptor Edg-1 ;
S1P receptor Edg-1 ;
CD antigen CD363
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Background:
The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
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Function:
Function:Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. Seems to be coupled to the G(i) subclass of heteromeric G proteins.,induction:By the tumor promoter phorbol 12-myristate 13-acetate (PME) in the presence of cycloheximide.,PTM:S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Endothelial cells, and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein. Endosome. Membrane raft. Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
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Tissue Expression:
Research Areas:
>>FoxO signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Neuroactive ligand-receptor interaction
>>Sphingolipid signaling pathway ;
>>Neuroactive ligand-receptor interaction
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Signaling Pathway
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Catalog: YT1460
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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