Catalog: YT1331
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
DGK-α
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IHC, IF, ELISA
MW
80kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
DGK-α Polyclonal Antibody detects endogenous levels of DGK-α protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human DGKA. AA range:304-353
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Specificity:
DGK-α Polyclonal Antibody detects endogenous levels of DGK-α protein.
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Gene Name:
DGKA
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Protein Name:
Diacylglycerol kinase alpha
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Other Name:
DGKA ;
DAGK ;
DAGK1 ;
Diacylglycerol kinase alpha ;
DAG kinase alpha ;
80 kDa diacylglycerol kinase ;
Diglyceride kinase alpha ;
DGK-alpha
DAGK ;
DAGK1 ;
Diacylglycerol kinase alpha ;
DAG kinase alpha ;
80 kDa diacylglycerol kinase ;
Diglyceride kinase alpha ;
DGK-alpha
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Background:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.,enzyme regulation:Stimulated by calcium and phosphatidylserine. Phosphorylated by protein kinase C.,Function:Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.,similarity:Belongs to the eukaryotic diacylglycerol kinase family.,similarity:Contains 1 DAGKc domain.,similarity:Contains 2 EF-hand domains.,similarity:Contains 2 phorbol-ester/DAG-type zinc fingers.,subunit:Monomer.,tissue specificity:Lymphocytes and oligodendroglial cells.,
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Cellular Localization:
Cytoplasm, cytosol .
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Tissue Expression:
Expressed in lymphocytes.
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Research Areas:
>>Glycerolipid metabolism ;
>>Glycerophospholipid metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phospholipase D signaling pathway ;
>>Choline metabolism in cancer
>>Glycerophospholipid metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phospholipase D signaling pathway ;
>>Choline metabolism in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT1331
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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