The antiserum was produced against synthesized peptide derived from human CaMK1-alpha. AA range:143-192

CaMKIα Polyclonal Antibody detects endogenous levels of CaMKIα protein.

CAMK1

Calcium/calmodulin-dependent protein kinase type 1

CAMK1 ;
Calcium/calmodulin-dependent protein kinase type 1 ;
CaM kinase I ;
CaM-KI ;
CaM kinase I alpha ;
CaMKI-alpha

Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Domain:The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.,enzyme regulation:Activated by Ca(2+)/calmodulin. Binding of calmodulin results in a conformational change that generates functional binding sites for both, substrate and ATP, and thus releaves intrasteric autoinhibition. Must be phosphorylated to be maximally active. Phosphorylated by CAMKK1 or CAMKK2.,Function:Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes like transcriptional regulation, hormone production, translational regulation, regulation of actin filament organization and neurite outgrowth. Involved in calcium-dependent activation of the ERK pathway (By similarity). Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CTFR, MYL9, SYN1/synapsin I and SYNII/synapsin II.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subcellular location:Predominantly cytoplasmic.,subunit:Monomer. Interacts with XPO1.,tissue specificity:Ubiquitous.,

Cytoplasm . Nucleus . Predominantly cytoplasmic. .

Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex.

>>Calcium signaling pathway ;
>>Oxytocin signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Glioma