Catalog: YT0498
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
BMP-2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
IF, WB, IHC, ELISA
MW
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IF 1:50-200; WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:10000; Not yet tested in other applications;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
60kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human BMP-2. AA range:226-275
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Specificity:
BMP-2 Polyclonal Antibody detects endogenous levels of BMP-2 protein.
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Gene Name:
BMP2
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Protein Name:
Bone morphogenetic protein 2
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Other Name:
BMP2 ;
BMP2A ;
Bone morphogenetic protein 2 ;
BMP-2 ;
Bone morphogenetic protein 2A ;
BMP-2A
BMP2A ;
Bone morphogenetic protein 2 ;
BMP-2 ;
Bone morphogenetic protein 2A ;
BMP-2A
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Database Link:
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016],
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Function:
Function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked. Interacts with GREM2 (By similarity) and SOSTDC1.,tissue specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.,
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Cellular Localization:
Secreted.
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Tissue Expression:
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>TGF-beta signaling pathway ;
>>Hippo signaling pathway ;
>>Pathways in cancer ;
>>Basal cell carcinoma
>>TGF-beta signaling pathway ;
>>Hippo signaling pathway ;
>>Pathways in cancer ;
>>Basal cell carcinoma
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Signaling Pathway
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: specific types >> Basal cell carcinoma
Environmental Information Processing >> Signal transduction >> TGF-beta signaling pathway
Environmental Information Processing >> Signal transduction >> Hippo signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YT0498
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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