Synthesized peptide derived from human PFKFB2 (Phospho Ser466)

This antibody detects endogenous levels of PFKFB2 (Phospho Ser466) Rabbit pAb at Human, Mouse,Rat

PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 ;
6PF-2-K/Fru-2,6-P2ase 2 ;
PFK/FBPase 2 ;
6PF-2-K/Fru-2,6-P2ase heart-type isozyme ;
[Includes: 6-phosphofructo-2-kinase ;
Fructose-2,6-bisphosphatase ;
]

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2(PFKFB2) Homo sapiens The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate.,Catalytic activity:Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate.,enzyme regulation:Phosphorylation results in the activation of the kinase activity.,Function:Synthesis and degradation of fructose 2,6-bisphosphate.,similarity:In the C-terminal section; belongs to the phosphoglycerate mutase family.,subunit:Homodimer.,tissue specificity:Heart.,

Heart.

>>Fructose and mannose metabolism ;
>>Metabolic pathways ;
>>AMPK signaling pathway ;
>>Thyroid hormone signaling pathway