Catalog: YP1554
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
YAP
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
67kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
67kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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YAP Rabbit pAb
YT4924
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Primary Antibodies
YAP (Phospho Ser127) Rabbit pAb
YP0708
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ELISA Kits
Total YAP Cell-Based Colorimetric ELISA Kit
KA3612C
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ELISA Kits
YAP (Phospho Ser127) Cell-Based Colorimetric ELISA Kit
KA1392C
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human YAP (Ser397)
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Specificity:
This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
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Gene Name:
YAP1 YAP65
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Protein Name:
YAP (Ser397)
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Other Name:
Yorkie homolog ;
65 kDa Yes-associated protein ;
YAP65 ;
65 kDa Yes-associated protein ;
YAP65 ;
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Database Link:
Background:
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
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Function:
PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
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Cellular Localization:
Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .
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Tissue Expression:
Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
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Research Areas:
>>Hippo signaling pathway ;
>>Hippo signaling pathway - multiple species
>>Hippo signaling pathway - multiple species
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YP1554
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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