Catalog: YP1464
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
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Collected
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Main Information
Target
REPS1
Host Species
Rabbit
Reactivity
Human, Rat, Mouse,
Applications
WB, IHC
MW
80kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human REPS1 (phospho-Ser709)
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
80kD
Modification
Phospho
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized phosho peptide around human REPS1 (Ser709)
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Specificity:
This antibody detects endogenous levels of Human REPS1 (phospho-Ser709)
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Gene Name:
REPS1
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Protein Name:
REPS1 (Ser709)
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Other Name:
RalBP1-associated Eps domain-containing protein 1 ;
RalBP1-interacting protein 1 ;
RalBP1-interacting protein 1 ;
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Background:
This gene encodes a signaling adaptor protein with two EH domains that interacts with proteins that participate in signaling, endocytosis and cytoskeletal changes. The encoded protein has been found in association with intersectin 1 and Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 when intersectin 1 was isolated from clathrin-coated pits. The encoded protein has also been shown to interact with amphiphysin, a cytoplasmic protein at the surface of synaptic vesicles. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014],
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Function:
Function:May coordinate the cellular actions of activated EGF receptors and Ral-GTPases.,PTM:EGF stimulates phosphorylation on Tyr-residues.,similarity:Contains 1 EF-hand domain.,similarity:Contains 1 EH domain.,subunit:Homodimer (Potential). Interacts with RAB11FIP2. Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase.,
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Cellular Localization:
Membrane, clathrin-coated pit . Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
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Tissue Expression:
Widely expressed with highest levels in heart and testis.
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Reference Citation({{totalcount}})
Catalog: YP1464
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
50μL
$190.00
In stock
0
Add to cart
Collected
Collect
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