The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser224. AA range:190-239

Phospho-ATRIP (S224) Polyclonal Antibody detects endogenous levels of ATRIP protein only when phosphorylated at S224.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HVsPR

ATRIP

ATR-interacting protein

ATRIP ;
AGS1 ;
ATR-interacting protein ;
ATM and Rad3-related-interacting protein

This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012],

Caution:The gene for this protein is either identical to or adjacent to that of TREX1. Some of the mRNAs that encode ATRIP also encode TREX1 in another reading frame.,Domain:The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.,Function:Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.,PTM:Phosphorylated by ATR.,sequence Caution:Translation N-terminally extended.,similarity:Belongs to the ATRIP family.,subcellular location:Redistributes to discrete nuclear foci upon DNA damage.,subunit:Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single stranded DNA. Interacts with CEP164 (via N-terminus).,tissue specificity:Ubiquitous.,

Nucleus . Redistributes to discrete nuclear foci upon DNA damage.

Ubiquitous.

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