The antiserum was produced against synthesized peptide derived from human CaMK2-beta/gamma/delta around the phosphorylation site of Thr287. AA range:253-302

Phospho-CaMKIIβ/γ/δ (T287) Polyclonal Antibody detects endogenous levels of CaMKIIβ/γ/δ protein only when phosphorylated at T287.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):QEtVE

CAMK2B

Calcium/calmodulin-dependent protein kinase type II subunit beta

CAMK2B ;
CAM2 ;
CAMK2 ;
CAMKB ;
Calcium/calmodulin-dependent protein kinase type II subunit beta ;
CaM kinase II subunit beta ;
CaMK-II subunit beta ;
CAMK2G ;
CAMK ;
CAMK-II ;
CAMKG ;
Calcium/calmodulin-dependent protein kinase type II subunit gamma ;

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],

Alternative products:The variable region of the CAMK2B protein is encoded by at least 7 exons (V1 to V7). Alternative splicing within this region gives rise to CAMK2B isoforms,Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Autophosphorylation of CAMK2 plays an important role in the regulation of the kinase activity.,Function:CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses, it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with SYNGAP1 and CAMK2N2 (By similarity). Interacts with MPDZ.,tissue specificity:Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain.,

Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Sarcoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse . In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR.

Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.

>>ErbB signaling pathway ;
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>HIF-1 signaling pathway ;
>>Oocyte meiosis ;
>>Necroptosis ;
>>Adrenergic signaling in cardiomyocytes ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Neurotrophin signaling pathway ;
>>Cholinergic synapse ;
>>Dopaminergic synapse ;
>>Olfactory transduction ;
>>Inflammatory mediator regulation of TRP channels ;
>>Insulin secretion ;
>>GnRH signaling pathway ;
>>Melanogenesis ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Aldosterone synthesis and secretion ;
>>Cushing syndrome ;
>>Gastric acid secretion ;
>>Parkinson disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Tuberculosis ;
>>Pathways in cancer ;
>>Proteoglycans in cancer ;
>>Glioma ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis