The antiserum was produced against synthesized peptide derived from human PDE4D around the phosphorylation site of Ser190/53. AA range:156-205

This antibody detects endogenous levels of PDE4B/C/D only when phosphorylated at Human:S190, Mouse:S129, Rat:S185..The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):REsFL

PDE4B/PDE4C/PDE4D

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

PDE4B ;
DPDE4 ;
cAMP-specific 3' ;
5'-cyclic phosphodiesterase 4B ;
DPDE4 ;
PDE32 ;
PDE4C ;
DPDE1 ;
cAMP-specific 3',5'-cyclic phosphodiesterase 4C ;
DPDE1 ;
PDE21 ;
PDE4D ;
DPDE3 ;
cAMP-specific 3',5'-cyclic phosphodiesterase 4D ;
DPDE3 ;
PDE43

This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014],

Alternative products:Additional isoforms seem to exist,Catalytic activity:Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.,enzyme regulation:Inhibited by rolipram.,Function:May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.,pathway:Purine metabolism; cAMP degradation; AMP from cAMP: step 1/1.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,tissue specificity:Expressed in brain, heart, lung and skeletal muscle.,

[Isoform PDE4B5]: Cytoplasm . Cell membrane .

Expressed in brain, heart, lung and skeletal muscle (PubMed:17519386). Expressed in white blood cells (PubMed:8392015). ; [Isoform PDE4B5]: Brain-specific isoform.

>>Purine metabolism ;
>>Metabolic pathways ;
>>cAMP signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Morphine addiction