The antiserum was produced against synthesized peptide derived from human NMDAR2B around the phosphorylation site of Tyr1474. AA range:1435-1484

Phospho-NMDAε2 (Y1474) Polyclonal Antibody detects endogenous levels of NMDAε2 protein only when phosphorylated at Y1474.The name of modified sites may be influenced by many factors, such as species (the modified site was not originally found in human samples) and the change of protein sequence (the previous protein sequence is incomplete, and the protein sequence may be prolonged with the development of protein sequencing technology). When naming, we will use the "numbers" in historical reference to keep the sites consistent with the reports. The antibody binds to the following modification sequence (lowercase letters are modification sites):HVyEK

GRIN2B

Glutamate [NMDA] receptor subunit epsilon-2

GRIN2B ;
NMDAR2B ;
Glutamate [NMDA] receptor subunit epsilon-2 ;
N-methyl D-aspartate receptor subtype 2B ;
NMDAR2B ;
NR2B ;
N-methyl-D-aspartate receptor subunit 3 ;
NR3 ;
hNR3

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008],

Function:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.,similarity:Belongs to the glutamate-gated ion channel (TC 1.A.10) family.,subunit:Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4. Interacts with HIP1 (By similarity). Interacts with MAGI3.,tissue specificity:Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.,

Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Late endosome . Lysosome . Cytoplasm, cytoskeleton . Co-localizes with the motor protein KIF17 along microtubules. .

Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.

>>Ras signaling pathway ;
>>Rap1 signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Circadian entrainment ;
>>Long-term potentiation ;
>>Glutamatergic synapse ;
>>Dopaminergic synapse ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Huntington disease ;
>>Spinocerebellar ataxia ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Amphetamine addiction ;
>>Nicotine addiction ;
>>Alcoholism ;
>>Systemic lupus erythematosus