Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
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Cellular Localization:
Membrane; Single-pass type I membrane protein.
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Tissue Expression:
Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.