Catalog: YN8257
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
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Main Information
Target
SH3RF2
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB
MW
80kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of SH3RF2 at Human, Mouse,Rat
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
80kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human SH3RF2
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Specificity:
This antibody detects endogenous levels of SH3RF2 at Human, Mouse,Rat
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Gene Name:
SH3RF2 PPP1R39 RNF158
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Protein Name:
Putative E3 ubiquitin-protein ligase SH3RF2 (Heart protein phosphatase 1-binding protein) (HEPP1) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (SH3 domain-containing RING finger protein 2)
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Database Link:
Function:
Has E3 ubiquitin-protein ligase activity . Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation . Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation . Inhibits PPP1CA phosphatase activity .
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Cellular Localization:
Nucleus .
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Tissue Expression:
Heart (at protein level). Up-regulated in colon cancer tissues as compared to normal colon tissues (at protein level). Testis. In the heart, present in the apex, left atrium, right atrium, left ventricle and right ventricle, but not in the aorta.
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Reference Citation({{totalcount}})
Catalog: YN8257
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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