Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation . In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity).
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Cellular Localization:
Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side .
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Tissue Expression:
Present in all adult tissues examined with the highest levels in skeletal muscle, heart, pancreas and testis.